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Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 34-47 doi: 10.1007/s11684-017-0606-8

Abstract: cells and antibody-producing B cells) achieve viral clearance and host recovery.Adaptive T and B cells maintain immunological memory and provide protection against subsequent infectionsRecent studies also shed light on the role of innate T-cells (MAIT cells, gd T cells, and NKT cells)We summarize the current knowledge on influenza-specific innate MAIT and gd T cells as well as adaptiveCD8+ and CD4+ T cells, and discuss how these responses can be harnessed by novel

Keywords： influenza     innate T cells     CD4+ and CD8+ T cells     vaccination    

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Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3

WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 366-369 doi: 10.1007/s11684-008-0070-6

Abstract: Virus-containing supernatant was applied to differentiate CD4CD25 T cells.The effect of transfected CD4 T cells on the proliferation and cytokine production of CD4CD25 T cellsFoxp3-gene transfected CD4 T cells could express Foxp3 and transfection of Foxp3 gene up-regulated theAfter transfection, the proliferation of CD4 T cells was eliminated.Transfected T cells inhibited the proliferation of CD4CD25 T cells.
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An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients

Jian Wang,Biyan Liang,Xiaoping Zhang,Liran Xu,Xin Deng,Xiuhui Li,Lu Fang,Xinghua Tan,Yuxiang Mao,Guoliang Zhang,Yuguang Wang

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 362-367 doi: 10.1007/s11684-014-0363-x

Abstract: Changes in the indexes of CD4 counts (≤200, 201–350, 351–500 and>500 cells/mm3For CD4 count of≤200 cells/mm3, the mean CD4 count changes were 21 and 28 cells/mmFor CD4 count of 201–350 cells/mm3, the mean CD4 count changes were 6 and 25 cells/mmFor CD4 count of 351–500 cells/mm3, the mean CD4 count changes were -13 and -7 cellsFor CD4 count of>500 cells/mm3, the mean CD4 count changes were -34 and -17 cells/mm

Keywords： AIDS     HIV     CD4     traditional Chinese medicine     linear models    

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Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associatedgene expression in t(8;21) acute myeloid leukemia

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 608-620 doi: 10.1007/s11684-021-0836-7

Abstract: t(8;21)(q22;q22) acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy withTwo leukemic myeloblast populations (CD34 CD117 and CD34 CD117 ) were previously identified in t(8;21Here, we examined the impact of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression on t(8;In this study, 85 patients with t(8;21) AML were enrolled.provide new clinically prognostic markers for t(8;21) AML.

Keywords： t(8     21)(q22     q22) AML     CD34+CD117dim/ CD34+CD117bri cell population    

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Biological features of intrahepatic CD4+CD25+ T cells in the naturally tolerance of rat liver transplantation

LU Ling, ZHANG Feng, PU Liyong, YAO Aihua, YU Yue, SUN Beicheng, LI Guoqiang, WANG Xuehao

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 373-376 doi: 10.1007/s11684-007-0072-9

Abstract: The biological features of intrahepatic CD4CD25 T regulatory cells in the naturally tolerance of ratThe purity of CD4CD25 T cells sorted by MACS was 86%–93%.The CD4CD25 T cells could specifically express the Foxp3 gene compared with CD4CD25 T cells. , the spleencells from LEW rats can irritate the proliferation of CD4CD25 T cells more obviously than the syngegnicCD4CD25 Tr cells could suppress the proliferation of CD4CD25 T cells, but the inhibition was reversed

Keywords： magnetic     LEW-to-DA     effector     MACS     cytometry    

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Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Frontiers of Medicine doi: 10.1007/s11684-023-1010-1

Abstract: Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Keywords： exosomes induce activation     impair function CD19     exosomal CD19 antigen    

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Clinical laboratory features of Meigs’ syndrome: a retrospective study from 2009 to 2018

Wenwen Shang, Lei Wu, Rui Xu, Xian Chen, Shasha Yao, Peijun Huang, Fang Wang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 116-124 doi: 10.1007/s11684-019-0732-6

Abstract: Serum carbohydrate antigen 125 and HE4 levels were higher in the MS group than in the ovarian thecoma-fibromaHowever, the serum HE4 levels were lower in the MS group than in the OC group ( <0.001).the glucose transporter 1, lactate dehydrogenase, and enolase 1 mRNA levels were lower in peripheral CD4T cells obtained preoperatively in a patient with MS than those in patients with OTF, patients with

Keywords： Meigs’ syndrome     ovarian thecoma-fibroma     NLR (neutrophil to lymphocyte ratio)     CD4+ T cells    

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Single and joint effects of HHCB and cadmium on zebrafish (

Lei ZHANG, Jing AN, Qixing ZHOU

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 3,   Pages 360-372 doi: 10.1007/s11783-011-0353-z

Abstract: Thus, single and joint toxic effects of 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8- hexamethylcyclopenta-gamma-2-benzopyran (HHCB) as one of the most widely applied artificial musks and cadmium (Cd) as an toxiczebrafish ( ) were investigated by the exposure of zebrafish to various concentrations of HHCB or/and Cdperoxidase (POD), and malondialdehyde (MDA) were sensitive and induced in the zebrafish stressed by CdJoint effects on antioxidant enzymes depended more on the effect of single Cd in the first one or two

Keywords： 1     3     4     6     7     8-hexahydro-4     6     6     7     8     8-hexamethylcyclopenta-gamma-2-benzopyran (HHCB)     cadmium (Cd)     antioxidant    

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CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells

Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 204-211 doi: 10.1007/s11684-016-0443-1

Abstract: involved in blood spread and liver metastasis of cancer cells by mediating the adhesion of cancer cellsto endothelial cells and hepatocytes, respectively.The purified scFv can bind to the natural CD176 expressed on the surface of cancer cells.Furthermore, the CD176 scFv inhibits the adhesion of CD176+ cancer cells to endothelialcells and hepatocytes.

Keywords： CD176     Thomsen-Friedenreich antigen     scFv     cancer     therapy     adhesion     metastasis    

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Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 139-149 doi: 10.1007/s11684-021-0835-8

Abstract: The CD19-targeting bispecific T-cell engager blinatumomab has shown remarkable efficacy in patients withnegative leukemic cells.positive T cells, enhancing T-cell function, mediating B-cell depletion, and eventually inhibiting tumorin cells missing CD19, suggesting its potential function against CD19 weak or negative CD20 positiveleukemic cells.

Keywords： B-cell acute lymphoblastic leukemia     bispecific antibody     trispecific antibody     CD19     CD20    

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tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19chimeric antigen receptor T therapy

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 699-713 doi: 10.1007/s11684-022-0972-8

Abstract: Anti-CD19 chimeric antigen receptor (CAR)-T cell therapy has achieved 40%–50A multi-center phase I/II trial of anti-CD19 CD28z CAR-T (FKC876, ChiCTR1800019661) was conducted.cells, leading to CAR-T cell therapy failure and disease progression in DLBCL.and disease progression, which could not be altered by infiltrating CAR-T cells.Aberrant metabolism profile of M2-subtype macrophages and those of dysfunctional T cells also contributed

Keywords： anti-CD19 chimeric antigen receptor T     immunotherapy     diffuse large B cell lymphoma     tumor microenvironment    

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AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 248-262 doi: 10.1007/s11684-012-0206-6

Abstract:

The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is presentin approximately 4%–12% of adult and 12%–30% of pediatric acute myeloid leukemia (AML) patientsWe also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting theRecently published studies suggest that a targeted therapy for t(8;21) positive AML is feasible and may

Keywords： AML1-ETO     mouse model     leukemia     t(8     21)     pathway hits     mutation     hematopoiesis     Kasumi-1     CD34+    

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Comparisons in subcellular and biochemical behaviors of cadmium between low-Cd and high-Cd accumulation

Meng XUE, Yihui ZHOU, Zhongyi YANG, Biyun LIN, Jiangang YUAN, Shanshan WU

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 2,   Pages 226-238 doi: 10.1007/s11783-013-0582-4

Abstract: in low-Cd accumulation cultivars and high-Cd accumulation cultivars of pakchoi ( L.).low-Cd cultivars.The high-Cd cultivars had significantly higher leaf and stem Cd concentrations than the low-Cd cultivarsthan high-Cd cultivars, leaf vacuole sequestrated higher proportions of Cd.Cd in the form of pectate/protein complexes (extracted by 1 mol·L NaCl) played a decisive role in Cd

Keywords： cadmium (Cd)     low-Cd cultivar     pakchoi (Brassica chinensis L.)    

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Exosomal CD44 Cooperates with Integrin α6β4 to Support Organotropic Metastasis via Regulating Tumor Cell Article

Wei Mu, Yajie Xu, Pengfei Gu, Wenbo Wang, Jingquan Li, Yang Ge, Hui Wang

Engineering 2021, Volume 7, Issue 10,   Pages 1415-1425 doi: 10.1016/j.eng.2020.08.013

Abstract: Exosomes derived from pancreatic cancer cells tend to be enriched in proteins that are anchored to theFor the first time, our study has demonstrated that CD44, a transmembrane glycoprotein delivered by exosomesMoreover, CD44 was found to interact with integrin α6β4 to form a complex, thereby remodelingNotably, we also demonstrated that the CD44–α6β4 complex can be delivered to the targetThe selective uptake of CD44-competent tumor exosomes by liver cells activated fibrotic pathways and

Keywords： Pancreatic cancer     Organotropic metastasis     Exosomes     Pre-metastatic niche     CD44    

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Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 285-294 doi: 10.1007/s11684-021-0843-8

Abstract: Anti-CD19 chimeric antigen receptor (CAR) T cell therapy has shown impressive efficacy in treating B-cellA single-center phase I dose-escalation study was conducted to evaluate the safety and efficacy of Tcells transduced with CBM.CD19 CAR, a second-generation anti-CD19 CAR bearing 4-1BB costimulatory moleculeTen heavily treated patients with refractory DLBCL were given CBM.CD19 CAR-T cell (C-CAR011) treatmentThe overall response rate was 20% and 50% at 4 and 12 weeks after the infusion of C-CAR011, respectively

Keywords： CAR-T cell therapy     refractory diffuse large B-cell lymphoma     cytokine release syndrome     dose-limiting    

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Title Author Date Type Operation

Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Journal Article

Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3

WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng

Journal Article

An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients

Jian Wang,Biyan Liang,Xiaoping Zhang,Liran Xu,Xin Deng,Xiuhui Li,Lu Fang,Xinghua Tan,Yuxiang Mao,Guoliang Zhang,Yuguang Wang

Journal Article

Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associatedgene expression in t(8;21) acute myeloid leukemia

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Journal Article

Biological features of intrahepatic CD4+CD25+ T cells in the naturally tolerance of rat liver transplantation

LU Ling, ZHANG Feng, PU Liyong, YAO Aihua, YU Yue, SUN Beicheng, LI Guoqiang, WANG Xuehao

Journal Article

Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Journal Article

Clinical laboratory features of Meigs’ syndrome: a retrospective study from 2009 to 2018

Wenwen Shang, Lei Wu, Rui Xu, Xian Chen, Shasha Yao, Peijun Huang, Fang Wang

Journal Article

Single and joint effects of HHCB and cadmium on zebrafish (

Lei ZHANG, Jing AN, Qixing ZHOU

Journal Article

CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells

Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao

Journal Article

Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific

Journal Article

tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19chimeric antigen receptor T therapy

Journal Article

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Journal Article

Comparisons in subcellular and biochemical behaviors of cadmium between low-Cd and high-Cd accumulation

Meng XUE, Yihui ZHOU, Zhongyi YANG, Biyun LIN, Jiangang YUAN, Shanshan WU

Journal Article

Exosomal CD44 Cooperates with Integrin α6β4 to Support Organotropic Metastasis via Regulating Tumor Cell

Wei Mu, Yajie Xu, Pengfei Gu, Wenbo Wang, Jingquan Li, Yang Ge, Hui Wang

Journal Article

Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large

Journal Article